Single-Voxel ¹ H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD⁺ ) in humans at 7T using a 32-channel volume coil.

ABSTRACT:

Purpose

Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD⁺ ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a ¹ H MRS pulse sequence for the in vivo, localized ¹ H MRS detection of NAD⁺ from the human brain.

Methods

Studies were carried out on a 7T Siemens MRI scanner using a 32-channel product volume coil. The pulse sequence consisted of a spectrally selective low bandwidth E-BURP-1 90° pulse. PRESS localization was achieved using optimized Shinnar-Le Roux 180° pulses and overlapping gradients were used to minimize the TE. The reproducibility of NAD⁺ quantification was measured in 11 healthy volunteers. The association of cerebral NAD<

SUBMITTER: Bagga P 

PROVIDER: S-EPMC6879788 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature