Inversion recovery UTE based volumetric myelin imaging in human brain using interleaved hybrid encoding.

ABSTRACT:

Purpose

Direct myelin imaging can improve the characterization of myelin-related diseases such as multiple sclerosis. In this study, we explore a novel method to directly image myelin using inversion recovery-prepared hybrid encoding (IR-HE) UTE MRI.

Methods

The IR-HE sequence uses an adiabatic inversion pulse to suppress the long T₂ white matter signal, followed by 3D dual-echo HE utilizing both single point imaging and radial frequency encoding, for which the subtraction image between 2 echoes reveals the myelin signal with high contrast. To reduce scan time, it is common to obtain multiple spokes per IR. Here, we invented a novel method to improve the HE, adapted for the multi-spoke IR imaging-termed interleaved HE-for which single point imaging encoding is int

SUBMITTER: Jang H 

PROVIDER: S-EPMC6879796 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature