Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate.

ABSTRACT: Growth rate and metabolic state of bacteria have been separately shown to affect antibiotic efficacy^1-3. However, the two are interrelated as bacterial growth inherently imposes a metabolic burden⁴; thus, determining individual contributions from each is challenging^5,6. Indeed, faster growth is often correlated with increased antibiotic efficacy^7,8; however, the concurrent role of metabolism in that relationship has not been well characterized. As a result, a clear understanding of the interdependence between growth and metabolism, and their implications for antibiotic efficacy, are lacking⁹. Here, we measured growth and metabolism in parallel across a broad range of coupled and uncoupled conditions to determine their relative contribu

SUBMITTER: Lopatkin AJ 

PROVIDER: S-EPMC6879803 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature