Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family.

ABSTRACT: Research on filoviruses has historically focused on the highly pathogenic ebola- and marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family. Recent advances in sequencing technologies have facilitated the discovery of not only a new ebolavirus, but also three new filovirus genera and a sixth proposed genus. While two of these new genera are similar to the ebola- and marburgviruses, the other two, discovered in saltwater fishes, are considerably more diverse. Nonetheless, these viruses retain a number of key features of the other filoviruses. Here, we review the key characteristics of filovirus replication and transcription, highlighting similarities and differences between the viruses. In particular, we focus on key regulatory elements in the genomes

SUBMITTER: Hume AJ 

PROVIDER: S-EPMC6879820 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature