Cyclophilin A protects HIV-1 from restriction by human TRIM5α.

ABSTRACT: The HIV-1 capsid (CA) protein lattice encases viral genomic RNA and regulates steps essential to target-cell invasion¹. Cyclophilin A (CypA) has interacted with the CA of lentiviruses related to HIV-1 for millions of years^2-7. Disruption of the CA-CypA interaction decreases HIV-1 infectivity in human cells^8-12 but stimulates infectivity in non-human primate cells^13-15. Genetic and biochemical data suggest that CypA protects HIV-1 from a CA-specific restriction factor in human cells^16-20. Discovery of the CA-specific restriction factor tripartite-containing motif 5α (TRIM5α)²¹ and multiple, independently derived, TRIM5-CypA fusion genes^4,5,15,22-26 pointed to human TRIM5α being the CypA-sensitive restriction factor

SUBMITTER: Kim K 

PROVIDER: S-EPMC6879858 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature