Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication.

ABSTRACT:

Objective

Understanding message delivery among vascular cells is essential for deciphering the intercellular communications in cardiovascular diseases. MicroRNA (miR)-92a is enriched in endothelial cells (ECs) and circulation under atheroprone conditions. Macrophages are the primary immune cells in atherosclerotic lesions that modulate lesion development. Therefore, we hypothesize that, in response to atheroprone stimuli, ECs export miR-92a to macrophages to regulate their functions and enhance atherosclerotic progression. Approach and Results: We investigated the macrophage functions that are regulated by EC miR-92a under atheroprone microenvironments. We first determined the distributions of functional extracellular miR-92a by fractionating the intravesicular and extravesicular c

SUBMITTER: Chang YJ 

PROVIDER: S-EPMC6879873 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature