The impact of skeletal muscle contraction on CD146⁺Lin^- pericytes.

ABSTRACT: Unaccustomed resistance exercise can initiate skeletal muscle remodeling and adaptive mechanisms that can confer protection from damage and enhanced strength with subsequent stimulation. The myofiber may provide the primary origin for adaptation, yet multiple mononuclear cell types within the surrounding connective tissue may also contribute. The purpose of this study was to evaluate the acute response of muscle-resident interstitial cells to contraction initiated by electrical stimulation (e-stim) and subsequently determine the contribution of pericytes to remodeling as a result of training. Mice were subjected to bilateral e-stim or sham treatment. Following a single session of e-stim, NG2⁺CD45^-CD31^- (NG2⁺Lin^-) pericyte, CD146^+<

SUBMITTER: Dvoretskiy S 

PROVIDER: S-EPMC6879875 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature