NanoTouch: intracellular recording using transmembrane conductive nanoparticles.

ABSTRACT: Observations of the electrophysiological properties of cells are important for understanding cellular functions and their underlying mechanisms. Short action potentials in axons are essential to rapidly deliver signals from the neuronal cell body to the terminals, whereas longer action potentials are required for sufficient calcium influx for transmitter release at the synaptic terminals and for cardiomyocyte and smooth muscle contractions. To accurately observe the shape and timing of depolarizations, it is essential to measure changes in the intracellular membrane potential. The ability to record action potentials and intracellular membrane potentials from mammalian cells and neurons was made possible by Ling and Gerard's discovery in 1949, when they introduced sharp glass electrode with

SUBMITTER: Saito ML 

PROVIDER: S-EPMC6879961 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature