Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging.

ABSTRACT:

Objective

To compare structure, functional connectivity (FC) and task-based neural differences in subjects with generalized anxiety disorder (GAD) compared to healthy controls (HC).

Methods

The Embase, Ovid Medline, PsycINFO, Scopus, and Web of Science databases were searched from inception until March 12, 2018. Two reviewers independently screened titles, abstracts, and full-text articles. Data were extracted from records directly contrasting GAD and HC that included structure (connectivity and local indices such as volume, etc.), FC, or task-based magnetic resonance imaging data. Meta-analyses were conducted, as applicable, using AES-SDM software.

Results

The literature search produced 4,645 total records, of which 85 met the inclusion criteria for the systematic re

SUBMITTER: Kolesar TA 

PROVIDER: S-EPMC6879983 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature