Deformation based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia.

ABSTRACT:

Objective

To objectively quantify how cerebral volume loss could assist with clinical diagnosis and clinical trial design in the behavioural variant of frontotemporal dementia (bvFTD).

Methods

We applied deformation-based morphometric analyses with robust registration to precisely quantify the magnitude and pattern of atrophy in patients with bvFTD as compared to cognitively normal controls (CNCs), to assess the progression of atrophy over one year follow up and to generate clinical trial sample size estimates to detect differences for the structures most sensitive to change. This study included 203 subjects - 70 bvFTD and 133 CNCs - with a total of 482 timepoints from the Frontotemporal Lobar Degeneration Neuroimaging Initiative.

Results

Deformation based morphometry

SUBMITTER: Manera AL 

PROVIDER: S-EPMC6879994 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature