White matter tracing combined with electric field simulation - A patient-specific approach for deep brain stimulation.

ABSTRACT:

Objective

Deep brain stimulation (DBS) in zona incerta (Zi) is used for symptom alleviation in essential tremor (ET). Zi is positioned along the dentato-rubro-thalamic tract (DRT). Electric field simulations with the finite element method (FEM) can be used for estimation of a volume where the stimulation affects the tissue by applying a fixed isolevel (V_DBS). This work aims to develop a workflow for combined patient-specific electric field simulation and white matter tracing of the DRT, and to investigate the influence on the V_DBS from different brain tissue models, lead design and stimulation modes. The novelty of this work lies in the combination of all these components.

Method

Patients with ET were implanted in Zi (lead 3389, n = 3, voltage mode; dir

SUBMITTER: Nordin T 

PROVIDER: S-EPMC6880013 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature