Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants.

ABSTRACT:

Introduction

The role of TOMM40-APOE 19q13.3 region variants is well documented in Alzheimer's disease (AD) but remains contentious in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).

Methods

We dissected genetic profiles within the TOMM40-APOE region in 451 individuals from four European brain banks, including DLB and PDD cases with/without neuropathological evidence of AD-related pathology and healthy controls.

Results

TOMM 40-L/APOE-ε4 alleles were associated with DLB (OR _{TOMM40 -L} = 3.61; P value = 3.23 × 10^-9; OR _{APOE -ε4} = 3.75; P value = 4.90 × 10^-10) and earlier age at onset of DLB (HR _TOMM40

SUBMITTER: Prokopenko I 

PROVIDER: S-EPMC6880091 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature