Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State.

ABSTRACT: Interferons (IFNs) induce the expression of interferon-stimulated genes (ISGs), many of which are responsible for the cellular antiviral state in which the replication of numerous viruses is blocked. How the majority of individual ISGs inhibit the replication of particular viruses is unknown. We conducted a loss-of-function screen to identify genes required for the activity of alpha interferon (IFN-α) against vesicular stomatitis virus, Indiana serotype (VSV_IND), a prototype negative-strand RNA virus. Our screen revealed that TRIM69, a member of the tripartite motif (TRIM) family of proteins, is a VSV_IND inhibitor. TRIM69 potently inhibited VSV_IND replication through a previously undescribed transcriptional inhibition mechanism. Specifically, TRIM69 physica

SUBMITTER: Kueck T 

PROVIDER: S-EPMC6880163 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature