Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

ABSTRACT:

Introduction

Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins.

Methods

4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid.

Results

A panel of proteins (n = 44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area und

SUBMITTER: Shi L 

PROVIDER: S-EPMC6880298 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature