Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment.

ABSTRACT: Immunotherapy is a currently popular treatment strategy for cancer patients. Although recent developments in cancer immunotherapy have had significant clinical impact, only a subset of patients exhibits clinical response. Therefore, understanding the molecular mechanisms of immunotherapy resistance is necessary. The mechanisms of immune escape appear to consist of two distinct tumor characteristics: a decrease in effective immunocyte infiltration and function and the accumulation of immunosuppressive cells in the tumor microenvironment. Several host-derived factors may also contribute to immune escape. Moreover, inter-patient heterogeneity predominantly results from differences in somatic mutations between cancers, which has led to the hypothesis that differential activation of specific tu

SUBMITTER: Yang L 

PROVIDER: S-EPMC6880373 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature