Development of a CRISPR/Cas9 system against ruminant animal brucellosis.

ABSTRACT: BACKGROUND:Brucellosis, caused by several Brucella species, such as the bacterium Brucella melitensis, is considered one of the most severe zoonotic diseases worldwide. Not only does it affect ruminant animal populations, leading to a substantial financial burden for stockbreeders, but also poses severe public health issues. For almost four decades in southern Europe and elsewhere, eradication of the disease has been based on ambiguously effective programs, rendering massive sanitation of livestock urgent and indispensable. Gene therapy, which has been proved effective in the clinic, could possibly constitute an alternative option towards a permanent cure for brucellosis, by aiding in the deletion or inactivation of genes associated with the replication of Brucella within the host cells. R

SUBMITTER: Karponi G 

PROVIDER: S-EPMC6880386 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature