The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?

ABSTRACT: Mitosis is the process whereby an eukaryotic cell divides into two identical copies. Different multiprotein complexes are involved in the fine regulation of cell division, including the mitotic promoting factor and the anaphase promoting complex. Prolonged mitosis can result in cellular division, cell death, or mitotic slippage, the latter leading to a new interphase without cellular division. Mitotic slippage is one of the causes of genomic instability and has an important therapeutic and clinical impact. It has been widely studied in solid tumors but not in hematological malignancies, in particular, in acute leukemia. We review the literature data available on mitotic regulation, alterations in mitotic proteins occurring in acute leukemia, induction of prolonged mitosis and its consequen

SUBMITTER: Ghelli Luserna di Rora A 

PROVIDER: S-EPMC6880427 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature