A comparative effectiveness analysis of the PBCG vs. PCPT risks calculators in a multi-ethnic cohort.

ABSTRACT:

Background

Predictive models that take race into account like the Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPT RC) and the new Prostate Biopsy Collaborative Group (PBCG) RC have been developed to equitably mitigate the overdiagnosis of prostate specific antigen (PSA) screening. Few studies have compared the performance of both calculators across racial groups.

Methods

From 1485 prospectively recruited participants, 954 men were identified undergoing initial prostate biopsy for abnormal PSA or digital rectal examination in five Chicago hospitals between 2009 and 2014. Discrimination, calibration, and frequency of avoided biopsies were calculated to assess the performance of both risk calculators.

Results

Of 954 participants, 463 (48.5%) were Black, 355 (3

SUBMITTER: Carbunaru S 

PROVIDER: S-EPMC6880480 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature