IL-17 inhibits CXCL9/10-mediated recruitment of CD8⁺ cytotoxic T cells and regulatory T cells to colorectal tumors.

ABSTRACT:

Background

The IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains unclear. IL-17 also dampens Th1-armed anti-tumor immunity, in part by attracting myeloid cells to tumor. Whether IL-17 controls the activity of adaptive immune cells in a more direct manner, however, is unknown.

Methods

Using mouse models of sporadic or inducible colorectal cancers, we ablated IL-17RA in the whole body or specifically in colorectal tumor cells. We also performed adoptive bone marrow reconstitution to knockout CXCR3 in hematopoietic cells. Histological and immunological experimental methods were used to reveal the link among IL-17, chemokine produ

SUBMITTER: Chen J 

PROVIDER: S-EPMC6880503 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature