A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin.

ABSTRACT:

Background

Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients with AS, ulcerative colitis (UC), and healthy controls (HC) and to determine relationships between fecal microbiota, fecal calprotectin, and disease-related variables in AS.

Methods

Fecal microbiota composition was assessed with GA-map™ Dysbiosis Test (Genetic Analysis, Oslo, Norway), which also reports the degree of deviation of the microbiota composition compared with a healthy control population, a Dysbiosis Index (DI) score 1-5. The AS patients were assessed

SUBMITTER: Klingberg E 

PROVIDER: S-EPMC6880506 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature