Kidney therapeutic potential of peptides derived from the bromelain hydrolysis of green peas protein.

ABSTRACT:

Objectives

Kidney disease is a global health problem that needs a solution to its therapy. In the previous study, we found that protein hydrolysate of green peas origin of Indonesia hydrolysed by bromelain (PHGPB) showed improve kidney function in cisplatin-induced nephropathy rats. In this study, we investigated the effect of PHGPB to obtain effective dose that exerts a therapeutic effect on chronic kidney disease (CKD) based on reducing urea and creatinine levels and to elucidate its mechanism of action.

Materials and methods

Two sets of experiments were conducted: (1) characteristics and proteomic profile of PHGPB, (2) in vivo test of PHGPB in gentamycin-induced Wistar rats, including urea and creatinine measurements, activities of antioxidant and kidney-related pe

SUBMITTER: Hidayat M 

PROVIDER: S-EPMC6880536 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature