Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood.

ABSTRACT:

Background

Late-onset Alzheimer's disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present study investigated epigenome-wide patterns of DNA methylation (5-methylcytosine, 5mC) and hydroxymethylation (5-hydroxymethylcytosine, 5hmC), as well as the abundance of unmodified cytosine (UC), in relation to AD.

Results

We identified epigenetic differences in AD patients (n = 45) as compared to age-matched controls (n = 35) in the middle temporal gyrus, pertaining to genomic regions close to or overlapping with genes such as OXT (- 3.76% 5mC, p_Šidák = 1.07E-06), CHRNB1 (+ 1.46% 5hmC, p_Šidák = 4.01E-04), RHBDF2 (- 3.45% UC, p_Šidák</

SUBMITTER: Lardenoije R 

PROVIDER: S-EPMC6880587 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature