Prostate cancer risk allele specific for African descent associates with pathologic stage at prostatectomy.

ABSTRACT:

Purpose

A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles show a strong association in African-American men. This study was designed to evaluate associations between 8q24 risk alleles and clinical variables, such as pathologic stage, age at diagnosis, and recurrence, in a case series of African-American men.

Experimental design

Peripheral blood DNA samples from 114 African-American men with prostate cancer, including 106 who had undergone radical prostatectomy, were genotyped for six single-nucleotide polymorphisms on three 8q24 regions. The presence of these single-nucleotide polymorphisms was compared w

SUBMITTER: Whitman EJ 

PROVIDER: S-EPMC6880746 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature