Gut microbiota alterations associated with reduced bone mineral density in older adults.

ABSTRACT:

Objective

To investigate compositional differences in the gut microbiota associated with bone homeostasis and fractures in a cohort of older adults.

Methods

Faecal microbiota profiles were determined from 181 individuals with osteopenia (n = 61) or osteoporosis (n = 60), and an age- and gender-matched group with normal BMD (n = 60). Analysis of the 16S (V3-V4 region) amplicon dataset classified to the genus level was used to identify significantly differentially abundant taxa. Adjustments were made for potential confounding variables identified from the literature using several statistical models.

Results

We identified six genera that were significantly altered in abundance in the osteoporosis or osteopenic groups compared with age- and gender-matched controls. A deta

SUBMITTER: Das M 

PROVIDER: S-EPMC6880854 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature