Markers of autoimmunity in immune thrombocytopenia: prevalence and prognostic significance.

ABSTRACT: Prior studies have demonstrated an increased prevalence of autoimmune markers in patients with immune thrombocytopenia (ITP). Clinical experience has suggested that there may be an association between autoimmune markers and poor outcomes in ITP, but current guidelines do not encourage routine testing in these patients. We retrospectively assessed the prevalence of autoimmune markers in adult patients with ITP from our institutional database and used multiple logistic regression analyses to test for an association between autoimmune marker positivity and thrombotic events or clinical remission. We also assessed whether positivity for common autoimmune markers was associated with positivity for platelet autoantibodies. There was a high rate of autoimmune marker positivity in this population,

SUBMITTER: Hollenhorst MA 

PROVIDER: S-EPMC6880886 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature