Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation.

ABSTRACT: BACKGROUND:Hypoxia is one of the key factors affecting the survival of islet cells transplanted via the portal vein. Blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) is the only imaging technique that can detect the level of blood oxygen level in vivo. However, so far no study has indicated that BOLD-fMRI can be applied to monitor the liver oxygen level after islet transplantation. OBJECTIVE:To evaluate the value of Carbogen-challenge BOLD MRI in assessing the level of hypoxia in liver tissue after portal microcapsules implanted. METHODS:Fifty-one New Zealand rabbits were randomly divided into three experimental groups (15 in each group) were transplanted microencapsulated 1000 microbeads/kg (PV1 group), 3000 microbeads/kg (PV2 group), 5000 microbeads/kg (PV3

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC6881018 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature