Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy.

ABSTRACT: Diabetes in the mother during pregnancy is a risk factor for birth defects and perinatal complications and can affect long-term health of the offspring through developmental programming of susceptibility to metabolic disease. We previously showed that Streptozotocin-induced maternal diabetes in mice is associated with altered cell differentiation and with smaller size of the placenta. Placental size and fetal size were affected by maternal diet in this model, and maternal diet also modulated the risk for neural tube defects. In the present study, we sought to determine the extent to which these effects might be mediated through altered expression of nutrient transporters, specifically glucose and fatty acid transporters in the placenta. Our results demonstrate that expression of several tr

SUBMITTER: Kappen C 

PROVIDER: S-EPMC6881028 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature