An in silico analysis of robust but fragile gene regulation links enhancer length to robustness.

ABSTRACT: Organisms must ensure that expression of genes is directed to the appropriate tissues at the correct times, while simultaneously ensuring that these gene regulatory systems are robust to perturbation. This idea is captured by a mathematical concept called r-robustness, which says that a system is robust to a perturbation in up to r - 1 randomly chosen parameters. r-robustness implies that the biological system has a small number of sensitive parameters and that this number can be used as a robustness measure. In this work we use this idea to investigate the robustness of gene regulation using a sequence level model of the Drosophila melanogaster gene even-skipped. We consider robustness with respect to mutations of the enhancer sequence and with respect to changes of the transcription fact

SUBMITTER: Barr K 

PROVIDER: S-EPMC6881076 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature