Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa.

ABSTRACT: Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus account for the adaptive potential of pathogens. One option is to exploit evolutionary trade-offs, like collateral sensitivity, where evolved resistance to one antibiotic causes hypersensitivity to another one. To date, the evolutionary stability and thus clinical utility of this trade-off is unclear. We performed a critical experimental test on this key requirement, using evolution experiments with Pseudomonas aeruginosa, and identified three main outcomes: (i) bacteria commonly failed to counter hypersensitivity and went extinct; (ii) hypersensitivity sometimes converted into multidrug resistance; and (iii) resistance gains frequently caused re-sensitization to the previous drug, thereby mai

SUBMITTER: Barbosa C 

PROVIDER: S-EPMC6881144 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature