Steady-state imaging with inhomogeneous magnetization transfer contrast using multiband radiofrequency pulses.

ABSTRACT:

Purpose

Inhomogeneous magnetization transfer (ihMT) is an emerging form of MRI contrast that may offer high specificity for myelinated tissue. Existing ihMT and pulsed MT sequences often use separate radiofrequency pulses for saturation and signal excitation. This study investigates the use of nonselective multiband radiofrequency pulses for simultaneous off-resonance saturation and on-resonance excitation specifically for generation of ihMT contrast within rapid steady-state pulse sequences.

Theory and methods

A matrix-based signal modeling approach was developed and applied for both balanced steady state free precession and spoiled gradient echo sequences, accounting specifically for multiband pulses. Phantom experiments were performed using a combination of balanced stead

SUBMITTER: Malik SJ 

PROVIDER: S-EPMC6881187 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature