Cromolyn sodium delays disease onset and is neuroprotective in the SOD1^G93A Mouse Model of amyotrophic lateral sclerosis.

ABSTRACT: Accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated an increase in microgliosis and astrogliosis in the lumbar spinal cord of SOD1^G93A transgenic mice before the onset of symptoms, a neuroinflammatory response which correlated with disease progression. Importantly, early stage homeostatic microglia enhanced motor neuron survival, while pro-inflammatory microglia were toxic to motor neurons in the SOD1^G93A mice. Recent studies from our group have demonstrated that cromolyn sodium, an FDA approved compound, exerts neuroprotective effects in mouse models of Alzheimer's disease by altering microglial cell activation. Here, we tested the n

SUBMITTER: Granucci EJ 

PROVIDER: S-EPMC6881366 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature