Acute Kidney Injury in the Outpatient Setting Associates with Risk of End-Stage Renal Disease and Death in Patients with CKD.

ABSTRACT: Current acute kidney injury (AKI) diagnostic criteria are restricted to the inpatient setting. We proposed a new AKI diagnostic algorithm for the outpatient setting and evaluate whether outpatient AKI (AKI_OPT) modifies the disease course among patients with chronic kidney disease (CKD) enrolled in the national predialysis registry. AKI_OPT was detected when a 50% increase in serum creatinine level or 35% decline in eGFR was observed in the 180-day period prior to enrollment in the predialysis care program. Outcomes were progression to end-stage renal disease (ESRD) and all-cause mortality. Association analyses were performed using multiple Cox regression and coarsened exact matching (CEM) analysis. Among 6,046 patients, 31.5% (1,905 patients) had developed AKI_OPT<

SUBMITTER: Yeh HC 

PROVIDER: S-EPMC6881443 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature