RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning.

ABSTRACT: The majority of our human genome transcribes into noncoding RNAs with unknown structures and functions. Obtaining functional clues for noncoding RNAs requires accurate base-pairing or secondary-structure prediction. However, the performance of such predictions by current folding-based algorithms has been stagnated for more than a decade. Here, we propose the use of deep contextual learning for base-pair prediction including those noncanonical and non-nested (pseudoknot) base pairs stabilized by tertiary interactions. Since only [Formula: see text]250 nonredundant, high-resolution RNA structures are available for model training, we utilize transfer learning from a model initially trained with a recent high-quality bpRNA dataset of [Formula: see text]10,000 nonredundant RNAs made available t

SUBMITTER: Singh J 

PROVIDER: S-EPMC6881452 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature