Analyses of molecular and histopathologic features and expression of PRAME by immunohistochemistry in mucosal melanomas.

ABSTRACT: Mucosal melanomas are rare, and less is known about the biomarkers of this subtype in comparison to cutaneous or uveal melanomas. Preferentially expressed antigen in melanoma (PRAME) has been studied as a tool for prognostication of uveal melanomas, and immunotherapy against PRAME-expressing tumor cells has already shown promise. Our goal was to retrospectively analyze 29 cases of mucosal melanomas at our institution to determine if any molecular and histopathologic prognosticators could be identified, as well as to study PRAME expression and its association with prognosis. We found that the majority of mucosal melanomas expressed PRAME and a high PRAME expression score predicted a poor prognosis. There was no association between prognosis and the histomorphologic features analyzed, such a

SUBMITTER: Toyama A 

PROVIDER: S-EPMC6881537 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature