Fibroblast activation protein restrains adipogenic differentiation and regulates matrix-mediated mTOR signaling.

ABSTRACT: Obesity is a risk factor for multiple diseases, including diabetes, cardiovascular disease, and cancer. Within obese adipose tissue, multiple factors contribute to creating a disease-promoting environment, including metabolic dysfunction, inflammation, and fibrosis. Recent evidence points to fibrotic responses, particularly extracellular matrix remodeling, in playing a highly functional role in the pathogenesis of obesity. Fibroblast activation protein plays an essential role in remodeling collagen-rich matrices in the context of fibrosis and cancer. We observed that FAP-null mice have increased weight compared to wild-type controls, and so investigated the role of FAP in regulating diet-induced obesity. Using genetically engineered mouse models and in-vitro cell-derived matrices, we demon

SUBMITTER: Blomberg R 

PROVIDER: S-EPMC6881546 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature