Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.

ABSTRACT: Neutrophils form an essential part of innate immunity against infection. Cancer chemotherapy-induced neutropenia (CCIN) is a condition in which the number of neutrophils in a patient's bloodstream is decreased, leading to increased susceptibility to infection. Granulocyte colony-stimulating factor (GCSF) has been the only approved treatment for CCIN over two decades. To date, CCIN-related infection and mortality remain a significant concern, as neutrophils generated in response to administered GCSF are functionally immature and cannot effectively fight infection. This review summarizes the molecular regulatory mechanisms of neutrophil granulocytic differentiation and innate immunity development, dissects the biology of GCSF in myeloid expansion, highlights the shortcomings of GCSF in CCIN

SUBMITTER: Abdel-Azim H 

PROVIDER: S-EPMC6881549 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature