Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians.

ABSTRACT:

Introduction

Keloid is defined as a benign proliferative scar that grows beyond the confines of the original insult to the skin, invading into adjacent normal tissue. The pathogenesis of keloid is complex, and many evidences suggest the influence of genetic factors, among them the polymorphisms of the TP53 gene encoding tumor protein p53.

Objective

To investigate the association of rs1042522 (c.215G>C, p.Arg72Pro) and rs17878362 (16-bp insertion/duplication in intron 3) variants, two most frequently analyzed TP53 functional polymorphisms and the risk of keloid in Polish patients.

Materials and methods

The rs1042522 and rs17878362 polymorphisms were identified by sequencing genomic DNA extracted from peripheral blood leukocytes of 86 keloid patients and f

SUBMITTER: Dmytrzak A 

PROVIDER: S-EPMC6881576 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature