CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.

ABSTRACT: The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through a variety of mechanisms it can become constitutively activated in the pathogenesis of cancer. This leads to chronic expression of genes that underlie malignant cellular behavior. However, STAT3 is known to interact with other proteins, which may modulate its function. Understanding these interactions can provide insights into novel aspects of STAT3 function and may also suggest strategies to therapeutically target the large number of cancers driven by constitutively activated STAT3. To identify critical modulators of STAT3 transcriptional f

SUBMITTER: Egusquiaguirre SP 

PROVIDER: S-EPMC6881650 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature