Study partner types and prediction of cognitive performance: implications to preclinical Alzheimer's trials.

ABSTRACT:

Background

Alzheimer's disease (AD) clinical trials require enrollment of a participant and a study partner, whose role includes assessing participant cognitive and functional performance. AD trials now investigate early stages of the disease, when participants are not cognitively impaired. This gives rise to the question of whether study partners or participants provide more information in these trials.

Methods

We used data from the AD Cooperative Study Prevention Instrument Project (ADCS-PI) to compare participant and study partner predictions of the participant's current and future cognitive state. We used the Cognitive Function Instrument (CFI) as a measure of evaluation of the participant's cognitive status and the modified ADCS Preclinical Alzheimer's Cognitive Composi

SUBMITTER: Nuno MM 

PROVIDER: S-EPMC6881999 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature