Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom.

ABSTRACT: Unlike the diagnosed Major Depressive Disorder, depressive symptomatology in the general population has received less attention in genome-wide association scan (GWAS) studies. Here we report a GWAS study on depressive symptomatology using a discovery-replication design and the following approaches: To improve the robustness of the phenotypic measure, we used longitudinal data and calculated mean scores for at least 3 observations for each individual. To maximize replicability, we used nearly identical genotyping platforms and identically constructed phenotypic measures in both the Discovery and Replication samples. We report one genome-wide significant hit; rs58682566 in the EPG5 gene was associated (p = 3.25E-08) with the mean of the depression symptom in the Discovery sample, without con

SUBMITTER: Mekli K 

PROVIDER: S-EPMC6882010 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature