Bioinformatics analysis of capsid protein of different subtypes rabbit hemorrhagic disease virus.

ABSTRACT:

Background

Rabbit Hemorrhagic Disease Virus (RHDV) belongs to the Caliciviridae family, is a highly lethal pathogen to rabbits. Increasing numbers of studies have demonstrated the existence of antigenic variation in RHDV, leading to the emergence of a new RHDV isolate (RHDVb). However, the underlying factors determining the emergence of the new RHDV and its unpredictable epidemiology remain unclear. To investigate these issues, we selected more than 184 partial and/or complete genome sequences of RHDV from GenBank and analyzed their phylogenetic relationships, divergence, and predicted protein modification sites.

Results

Phylogenetic analysis showed that classic RHDV isolates, RHDVa, and RHDVb formed different clades. It's interesting to note that RHDVa being more closely re

SUBMITTER: Qi R 

PROVIDER: S-EPMC6882040 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature