A newly noninvasive model for prediction of non-alcoholic fatty liver disease: utility of serum prolactin levels.

ABSTRACT:

Backgrounds

To investigate the value of prolactin (PRL) in diagnosing non-alcoholic fatty liver disease (NAFLD).

Methods

Metabolic parameters and serum PRL levels were measured in 452 males and 421 females, who were randomized to the estimation or the validation group as a 1:1 ratio. Hepatic steatosis was diagnosed via abdominal ultrasound. Variables that significantly associated with NAFLD in univariate analysis were included in multiple logistic regression. We used the receiver operator characteristic (ROC) curves to test the model performance. Besides, 147 patients underwent metabolic and liver biopsy were analyzed to validate the diagnostic value of this model.

Results

Body mass index, alanine aminotransferase, prolactin, high density lipoprotein cholesterol and H

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6882057 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature