Low lean mass and chemotherapy toxicity risk in the elderly: the Fraction study protocol.

ABSTRACT: BACKGROUND:Half of cancer cases occur in patients aged 70 and above. Majority of older patients are eligible for chemotherapy but evidence for treating this population is sparse and severe toxicities affect more than half of them. Determining prognostic biomarkers able to predict poor chemotherapy tolerance remains one of the major issues in geriatric oncology. Ageing is associated with body composition changes (increase of fat mass and loss of lean mass) independently of weight-loss. Previous studies suggest that body composition parameters (particularly muscle mass) may predict poor chemotherapy tolerance. However, studies specifically including older adults on this subject remain sparse and the majority of them study body composition based on computed tomography (CT) scanner (axial L3 s

SUBMITTER: Steinmeyer Z 

PROVIDER: S-EPMC6882112 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature