Mortality risk over time after early fluid resuscitation in African children.

ABSTRACT:

Background

African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk associated with fluid boluses, but the temporal relationship to bolus therapy and underlying mechanism remains unclear.

Methods

In a post hoc retrospective analysis, flexible parametric models were used to compare change in mortality risk post-randomisation in children allocated to bolus therapy with 20-40 ml/kg 5% albumin or 0.9% saline over 1-2 h or no bolus (control, 4 ml/kg/hour maintenance), overall and for different terminal clinical events (cardiogenic, neurological, respiratory, or unknown/other).

Results

Two thousand ninety-seven and 1041 children wer

SUBMITTER: George EC 

PROVIDER: S-EPMC6882199 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature