Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol.

ABSTRACT: BACKGROUND:Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecules with the ability to modulate gene expressions and affect growth and regulation of embryo during pregnancy. Systematic review aims to evaluate age-related alterations in the exosomal content and functions that can influence the reproductive performance in human and animal models as conveyors of senescence signals. METHODS:A literature search of electronic databases including MEDLINE (PubMed), Embase, ProQuest, Scopus, Google Scholar, WHO, SID, MAGIRAN, and Barakat will be conducted. Following the online search, articles will be screened by two independent reviewers accordi

SUBMITTER: Mobarak H 

PROVIDER: S-EPMC6882206 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature