The effect of pilocarpine on dental caries in patients with primary Sjogren's syndrome: a database prospective cohort study.

ABSTRACT: BACKGROUND:Primary Sjögren's syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the risk of dental caries decreases with the use of pilocarpine in patients with pSS. METHODS:For this prospective cohort study, we identified pSS patients from the catastrophic illnesses registry of the National Health Insurance Research Database of Taiwan between 2009 and 2013. We divided participants into pilocarpine and non-user groups based on the pilocarpine prescriptions available during the first 3-month follow-up. The primary endpoint was dental caries. The secondary endpoints were periodontitis and oral candidiasis. We compared the risk of these oral manifestations u

SUBMITTER: Hsu CY 

PROVIDER: S-EPMC6882320 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature