Manhattan++: displaying genome-wide association summary statistics with multiple annotation layers.

ABSTRACT:

Background

Over the last 10 years, there have been over 3300 genome-wide association studies (GWAS). Almost every GWAS study provides a Manhattan plot either as a main figure or in the supplement. Several software packages can generate a Manhattan plot, but they are all limited in the extent to which they can annotate gene-names, allele frequencies, and variants having high impact on gene function or provide any other added information or flexibility. Furthermore, in a conventional Manhattan plot, there is no way of distinguishing a locus identified due to a single variant with very significant p-value from a locus with multiple variants which appear to be in a haplotype block having very similar p-values.

Results

Here we present a software tool written in R, which generates

SUBMITTER: Grace C 

PROVIDER: S-EPMC6882345 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature