Diurnal variation of inflammatory plasma proteins involved in pain.

ABSTRACT:

Introduction

Proteomics is a powerful approach for biochemical research because it directly studies the main functional components of biochemical systems. The understanding of the normal fluctuations of the proteome in health is essential to identify pain-specific biomarkers.

Objective

To investigate fluctuations of the plasma proteome in healthy pain-free individuals.

Methods

Blood samples were structurally collected in the early morning and evening from 10 clinically healthy individuals (26.3 ± 3.3 years). High abundant proteins were removed from plasma, and proteins were then analysed by nanoliquid chromatography combined with mass spectrometry. In addition, an assay of 71 cytokines/chemokines/growth factors was analysed.

Results

Multivariate statistical ana

SUBMITTER: Jasim H 

PROVIDER: S-EPMC6882578 | biostudies-literature | 2019 Sep-Oct

REPOSITORIES: biostudies-literature