Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage.

ABSTRACT: Actinic Keratosis (AK), Intraepidermal Carcinoma (IEC), and Squamous Cell Carcinoma (SCC) are generally considered to be advancing stages of the same disease spectrum. However, while AK often regress spontaneously, and IEC often regress in response to immune-activating treatments, SCC typically do not regress. Therefore, it is vital to define whether fundamental immunological changes occur during progression to SCC. Here we show that proinflammatory cytokine expression, chemokine expression, and immune cell infiltration density change during progression to SCC. Our findings suggest a switch from predominantly proinflammatory cytokine production to chemokine production is a key feature of progression from precancer to cancer. Together, these observations propose a model that can underpin cu

SUBMITTER: Tuong ZK 

PROVIDER: S-EPMC6882799 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature