The protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation.

ABSTRACT: Two distinct p38 signaling pathways, classical and alternative, have been identified to regulate inflammatory responses in host defense and disease development. The role of alternative p38 activation in liver inflammation is elusive, while classical p38 signaling in hepatocytes plays a role in regulating the induction of cell death in autoimmune-mediated acute liver injury. In this study, we found that a mutation of alternative p38 in mice augmented the severity of acute liver inflammation. Moreover, TNF-induced hepatocyte death was augmented by a mutation of alternative p38, suggesting that alternative p38 signaling in hepatocytes contributed more significantly to the pathology of acute liver injury. Furthermore, SYK-Vav-1 signaling regulates alternative p38 activation and the downregulat

SUBMITTER: Bang BR 

PROVIDER: S-EPMC6882802 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature